Glycodelin-A as a modulator of trophoblast invasion
نویسندگان
چکیده
منابع مشابه
Glycodelin-A as a modulator of trophoblast invasion.
BACKGROUND Trophoblast invasion is crucial to placentation. The relationship between decidual glycodelin-A and trophoblast invasion is not known. METHODS Invasiveness of First trimester extravillous cytotrophoblast-1 (TEV-1) cell line, TEV-1, cells was determined by trans-well invasion assay. The gene expression, protein secretion and activities of the matrix metalloproteinase (MMP)-2 and -9,...
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15 صفحه اولA Mathematical Model of Trophoblast Invasion
In this paper we present a simple mathematical model to describe the initial phase of placental development during which trophoblast cells invade the uterine tissue as a continuous mass of cells. The key physical variables involved in this crucial stage of mammalian development are assumed to be the invading trophoblast cells, the uterine tissue, trophoblast-derived proteases that degrade the u...
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Stimulation of progesterone, estradiol and cortisol in trophoblast tumor bewo cells by glycodelin A N-glycans.
BACKGROUND The immunosuppressive protein glycodelin A (GdA) is secreted by a large number of gynaecological tumors. GdA has a unique glycosylation, including fucosylated LacdiNAc structures. Trophoblast tumor cells produce a variety of steroid hormones and human chorionic gonadotropin (hCG). The purpose of this study was to investigate the effect of GdA N-glycans on hCG, cortisol, estradiol and...
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 2009
ISSN: 0268-1161,1460-2350
DOI: 10.1093/humrep/dep205